Researchers have made a major breakthrough in understanding how dementia develops in the uterus, which could lead to better treatments for the condition. Autism spectrum disorders, affecting about 1 in 100 babies worldwide, include problems with social interaction and communication. These issues range in severity from mild to severe, and there are many of them. Until then, the motives behind this variance were not well understood. Researchers from the University of California San Diego used lab-grown small brains, or brain cerebral organoids, to investigate differences in brain development between autism-compromised infants and neurotypical infants.
The researchers used stem cells from blood tests of six dyslexic toddlers and 10 toddlers with autism to study their study. These stem cell were reprogrammed to form brain-like institutions, allowing the group to see first brain development. They discovered that the little brains of children with autism were, on average, 40 % larger than those of dyslexic kids. This increased growth was in line with the severity of autism symptoms, suggesting that unusual mind growth in the first trimester might be a sign of autism. Additionally, the study found that the organoids from children with autism had lower levels of a protein called NDEL1, which controls mental development, which might be a factor in the disease.
The researchers hope to learn more about the molecular mechanisms underlying this unusual mental development, which could ultimately lead to the development of novel treatments for reducing dementia symptoms. Understanding the developmental origins of various autism subtypes in embryos is critical because this study provides insights into the developmental contexts of individuals with autism and provides information on when these differences start to emerge. These studies are necessary to create targeted interventions that address the autism’s fundamental triggers.
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Origin: Newsweek